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Investigating the Contribution of Peri-domestic Transmission to Risk of Zoonotic Malaria Infection in Humans
Authors:Benny O. Manin  Heather M. Ferguson  Indra Vythilingam  Kim Fornace  Timothy William  Steve J. Torr  Chris Drakeley  Tock H. Chua
Abstract:BackgroundIn recent years, the primate malaria Plasmodium knowlesi has emerged in human populations throughout South East Asia, with the largest hotspot being in Sabah, Malaysian Borneo. Control efforts are hindered by limited knowledge of where and when people get exposed to mosquito vectors. It is assumed that exposure occurs primarily when people are working in forest areas, but the role of other potential exposure routes (including domestic or peri-domestic transmission) has not been thoroughly investigated.Conclusions/SignificanceThis study shows there is a possibility that humans can be exposed to P. knowlesi infection around their homes. The vector is highly exophagic and few were caught indoors indicating interventions using bednets inside households may have relatively little impact.
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