Effect of tumour-promoting phorbol ester on calcium homeostasis in human platelets. |
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Authors: | M Lucas F Solano |
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Affiliation: | Departmento de Bioquímica, Hospital Universitario Virgen Macarena, Facultad de Medicina, Sevilla, Spain. |
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Abstract: | The more interesting features of the effects or PMA on [Ca2+]i and ATP release were the following: 1. preincubation with PMA inhibited thrombin-evoked calcium transients; 2. PMA stimulated slightly the release of calcium and ATP whereas inhibited calcium and ATP pools sensitive to thrombin; 3. A23187 reversed the inhibitory effect of PMA; 4. subsaturating thrombin concentrations gave results similar to PMA on thrombin-induced calcium and ATP release but not on [Ca2+]i. |
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