Alkylbenzoquinones with antiproliferative effect against human cancer cell lines from stem of Ardisia kivuensis |
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| Authors: | Blanche L. Ndonsta,Joel S.N. Tatsimo,Dezs? Csupor,Peter Forgo,Robert Berkecz,Á gnes Beré nyi,Mathieu Tene,Judit Molná r,Istvá n Zupkó ,Judit Hohmann,Pierre Tane |
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| Affiliation: | aDepartment of Chemistry, Faculty of Science, University of Dschang, Box 67, Dschang, Cameroon;bDepartment of Chemistry, Higher Teachers’ Training College, University of Maroua, PO Box 55, Maroua, Cameroon;cDepartment of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary;dDepartment of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary;eDepartment of Pharmacodynamics and Biopharmacy, Eötvös u. 6, University of Szeged, H-6720 Szeged, Hungary |
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| Abstract: | Two new alkylbenzoquinone derivatives, named as ardisiaquinone J (1) and K (2) were isolated from the MeOH extract of the stem of Ardisia kivuensis Taton (Myrsinaceae), together with the known lupeol and β-sitosterol. Their structures were elucidated on the basis of spectroscopic analysis and comparison with authentic samples. The new compounds exhibited considerable antiproliferative activity against Ishikawa, HeLa, MCF7 and A431 cell lines with IC50 values between 6.64 and 15.40 μM. In addition, compound 2 exerted a moderate free radical scavenging effect on DPPH-assay. |
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| Keywords: | Ardisia kivuensis Myrsinaceae Ardisiaquinone Antiproliferative Antioxidant activity |
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