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A new bioactive compound from the roots of Petasites hybridus |
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| Authors: | Fatemeh Khaleghi Laily Bin Din Faramarz Rostami Charati Wan Ahmad Yaacob Mohammad A Khalilzadeh Brian Skelton Mohamed Makha |
| Institution: | aSchool of Chemical Sciences and Food Technology, Faculty of Science and Technology, University Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia;bGonbad Higher Education Center, P.O. Box 163, Gonbad, Iran;cDepartment of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran;dSchool of Biomedical, Biomolecular and Chemical Sciences, M310, University of Western Australia, Perth, WA 6009, Australia |
| Abstract: | A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48 μmol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV–vis spectroscopy. |
| Keywords: | Petasites hybridus Benzofuran derivatie Bovine serum albumin (BSA) Human breast cancer MCF-7 DNA |
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