Antiprotozoal alkaloids from Galanthus trojanus |
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| Authors: | Gulen Irem Kaya Buket Sar?kaya Mustafa Ali Onur Nehir Unver Somer Francesc Viladomat Carles Codina Jaume Bastida Ina L Lauinger Marcel Kaiser Deniz Tasdemir |
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| Institution: | aEge University, Faculty of Pharmacy, Department of Pharmacognosy, Bornova, 35100 Izmir, Turkey;bDepartament de Productes Naturals, Biologia Vegetal I Edafologia, Facultat de Farmacia, Universitat de Barcelona, 08028 Barcelona, Spain;cCentre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, United Kingdom;dDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Socinstr. 57, CH-4002, Basel, Switzerland |
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| Abstract: | Two new alkaloid N-oxides, 1-O-acetyldihydromethylpseudolycorine N-oxide, and 11-hydroxyvittatine N-oxide, ten known alkaloids; arolycoricidine, haemanthamine, O-methylnorbelladine, narcidine, dihydrolycorine, 8-O-demethylmaritidine, stylopine and protopine, nicotinic acid and tyramine were isolated from Galanthus trojanus A.P. Davis & N. Özhatay (Amaryllidaceae). The chemical structures of the isolates were elucidated by UV, IR, MS, CD, 1D and 2D NMR experiments. The in vitro antiprotozoal and cytotoxic potentials of the compounds were also evaluated. |
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| Keywords: | Galanthus trojanus Amaryllidaceae Antimalarial activity Alkaloid N-oxides |
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