An amorphane sesquiterpene and a benzofuran glucoside from Eupatorium coelestinum |
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| Authors: | Dan Thi Thuy Hang Tran Thi Hong Hanh Chau Van Minh Phan Van Kiem Tran Huy Thai Dongho Lee Nguyen Tien Dat |
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| Institution: | aInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Viet Nam;bInstitute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Viet Nam;cSchool of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea |
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| Abstract: | A phytochemical investigation of the aerial parts of Eupatorium coelestinum led to the isolation of an amorphane sesquiterpene and a benzofuran glucoside. By means of spectroscopic methods, their structures were determined as 5α,8α-epoxy-4α,6β-dihydroxyamorphan-2-one (1) and 2R*,3S*-toxol-7-O-β-d-glucopyranoside (2). Compounds 1 significantly inhibited NF-κB activity in TNF-α-stimulated HeLa cells with the IC50 of 12.4 μM. |
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| Keywords: | Eupatorium coelestinum Asteraceae Amorphane sesquiterpene Benzofuran NF-κB |
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