Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats |
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| Authors: | Hossam M Abdallah Maha M Salama Enas H Abd-elrahman Shohda A El-Maraghy |
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| Institution: | aDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;bDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt;cDepartment of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt |
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| Abstract: | The n-butanol fraction (BF) of bark of Pecan tree, Carya illinoinensis (Wangenh) K. Koch (Juglandaceae) afforded two new flavonol methyl ether: caryatin-3′ sulfate (6) and caryatin-3′ methyl ether-7-O-β-d-glucoside (7) while five known phenolics (1–5) were isolated from its ethyl acetate fraction (EAF). The structures of isolated compounds were established based on 1D and 2D NMR spectroscopy. The isolated compounds were investigated for their hypoglycaemic, antioxidant as well as the aldose reductase (AR) inhibitory effect in lenses of streptozocin diabetic rats. All the isolated compounds showed significant hypoglycaemic and antioxidant activities, except 5 and 6. A marked AR-inhibitory effect was identified for compounds 2, 3 and 7. |
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| Keywords: | Pecan bark Aldose reductase Methoxy flavonoids Sulphated flavonoids Antidiabetic |
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