Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium |
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| Authors: | Richard L Mort Thaya Ramaesh Dirk A Kleinjan Steven D Morley and John D West |
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| Institution: | (1) Division of Reproductive and Developmental Sciences, Genes and Development Group, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK;(2) MRC Human Genetics Unit, Crewe Road, Edinburgh, EH4 2XU, UK;(3) Clinical Biochemistry Section, Division of Reproductive & Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK |
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| Abstract: | Background The mouse corneal epithelium is a continuously renewing 5–6 cell thick protective layer covering the corneal surface, which
regenerates rapidly when injured. It is maintained by peripherally located limbal stem cells (LSCs) that produce transient
amplifying cells (TACs) which proliferate, migrate centripetally, differentiate and are eventually shed from the epithelial
surface. LSC activity is required both for normal tissue maintenance and wound healing. Mosaic analysis can provide insights
into LSC function, cell movement and cell mixing during tissue maintenance and repair. The present study investigates cell
streaming during corneal maintenance and repair and changes in LSC function with age. |
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