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Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat |
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| Authors: | Zannatul Ferdous Muhammad Anwar Qureshi Petrilla Jayaprakash Khatija Parekh Annie John Murat Oz Haider Raza Halina Dobrzynski Thomas Edward Adrian Frank Christopher Howarth |
| Institution: | 1Department of Physiology, College of Medicine & Health Sciences, UAE University, Al Ain, UAE;2Department of Biochemistry, College of Medicine & Health Sciences, UAE University, Al Ain, UAE;3Department of Pharmacology, College of Medicine & Health Sciences, UAE University, Al AIn, UAE;4Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom;New York Medical College, UNITED STATES |
| Abstract: | BackgroundExperiments in isolated perfused heart have shown that heart rate is lower and sinoatrial node (SAN) action potential duration is longer in streptozotocin (STZ)–induced diabetic rat compared to controls. In sino-atrial preparations the pacemaker cycle length and sino-atrial conduction time are prolonged in STZ heart. To further clarify the molecular basis of electrical disturbances in the diabetic heart the profile of mRNA encoding a wide variety of proteins associated with the generation and transmission of electrical activity has been evaluated in the SAN of STZ-induced diabetic rat heart.Conclusions/SignificanceCollectively, this study has demonstrated differences in the profile of mRNA encoding a variety of proteins that are associated with the generation, conduction and regulation of electrical signals in the SAN of STZ-induced diabetic rat heart. Data from this study will provide a basis for a substantial range of future studies to investigate whether these changes in mRNA translate into changes in electrophysiological function. |
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