Correspondent reaction of mitotic recombination in yeast and sister chromatid exchange in human lymphocytes |
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Authors: | Rudolf Fahrig |
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Affiliation: | (1) Institut für Humangenetik und Anthropologie der Universität, Albertstr. 11, D-7800 Freiburg, Federal Republic of Germany;(2) Present address: Institut für Toxikologie der Universität, Wilhelmstr. 56, D-7400 Tübingen, Federal Republic of Germany |
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Abstract: | Summary In the lower eukaryote Saccharomyces cerevisiae, 4,5,6-trichloro-2-(dichlorophenoxy)phenol and acridine orange cause different specific genetic alterations, either gene mutations or recombinations. These specific effects were used to characterize the mechanism of sister chromatid exchange (SCE) formation in human lymphocytes. Assuming that genetically active substances have comparable effects in lower and higher eukaryotes, the observations provide indirect evidence for a connection between induced mitotic recombination in yeast and SCEs in human lymphocytes and suggest that SCEs may be the consequence of a repair process. |
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