MassSieve: Panning MS/MS peptide data for proteins |
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| Authors: | Douglas J Slotta Melinda A McFarland Sanford P Markey |
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| Institution: | Laboratory of Neurotoxicology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA |
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| Abstract: | We present MassSieve, a Java‐based platform for visualization and parsimony analysis of single and comparative LC‐MS/MS database search engine results. The success of mass spectrometric peptide sequence assignment algorithms has led to the need for a tool to merge and evaluate the increasing data set sizes that result from LC‐MS/MS‐based shotgun proteomic experiments. MassSieve supports reports from multiple search engines with differing search characteristics, which can increase peptide sequence coverage and/or identify conflicting or ambiguous spectral assignments. |
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| Keywords: | Bioinformatics MS Parsimony Protein identification |
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