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Identification of unusual truncated forms of nucleocapsid protein in MDCK cells infected by Avian influenza virus (H9N2) |
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| Authors: | Ning Liu Wenjun Song Pui Wang Kim‐Chung Lee Zongwei Cai Honglin Chen |
| Affiliation: | 1. Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, P. R. China;2. The Central Laboratory, The Second Hospital of Jilin University, Changchun, P. R. China;3. State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, P. R. China;4. Department of Chemistry, Fuzhou University, Fuzhou, P. R. China |
| Abstract: | Unusual truncated forms of nucleocapsid protein (NP) were identified in the lysate of MDCK cells infected by Avian influenza virus (H9N2) using MS‐based proteomics approach. Moreover, O‐sulfonation that was considered as an unusual modification was identified in one of the tryptic peptides from the truncated NP. The findings might have implications on better understanding on the role of nucleoprotein in Avian influenza virus–host interaction. |
| Keywords: | Avian influenza virus (H9N2) Cell biology MDCK cells Sulfonation Truncated nucleocapsid protein |