Expression of Presenilin 1 mRNA in Rat Peripheral Organs and Brain |
| |
Authors: | Camilla Nilsberth Johan Luthman Lars Lannfelt and Marianne Schultzberg |
| |
Institution: | (1) Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Division of Geriatric Medicine, Karolinska Institute, S-141 86 Huddinge, Sweden;(2) Cell Biology, Preclinical R&D, Astra Arcus AB, S-151 85 Södertälje, Sweden |
| |
Abstract: | At least 50 different mutations in the presenilin 1 gene have been shown to cause early onset familial Alzheimer's disease. Although presenilin 1 has an obvious role in the pathogenesis of Alzheimer's disease, its function is still unknown. In the present study, the occurrence and distribution of presenilin 1 mRNA was examined in rat peripheral organs as well as in the brain by in situ hybridization histochemistry, using a radiolabelled oligonucleotide probe. In comparison to the brain, a high presenilin 1 mRNA expression was found in the testis, kidney, spleen, adrenal gland and thymus. It was also observed in skeletal muscle, liver, small intestine and lung, whereas no presenilin 1 could be detected in the heart, spinal cord and pancreas. Since presenilin 1 mRNA was found to be abundant in peripheral tissues which apparently are not affected in Alzheimer's disease, additional functions of presenilin 1 are suggested, unrelated to its role in the pathological processes of the disease. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|