L-histidine-induced suppression of lipogenic enzymes. |
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Authors: | B Eichelman J K Solomon A A Qureshi |
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Institution: | 1. Laboratory of Behavioral Neurochemistry, William S. Middleton V.A. Hospital Madison, Wisconsin 53705 USA;2. Waisman Center, University of Wisconsin Madison, Wisconsin 53705 USA |
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Abstract: | Diets supplemented 5% with L-histidine produce hypercholesterolemia and increase cholesterol biosynthesis in rat liver. We now report an effect of L-histidine on lipogenic enzymes in the liver. In this study, L-histidine was added to chow and fat-free diets and fed to rats for 18 days. After two days of fasting, the rats were refed the same diet for three days prior to sacrifice. L-histidine decreased fatty acid synthetase activity by 51% when it was added to the chow diet and by 26% when it was added to the fat-free diet. Isocitrate dehydrogenase activity was not altered significantly in rats fed diets supplemented with L-histidine. |
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