| 脑部乳酸供能的方式 |
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| 引用本文： | 王今越,王小虹,陈民盛,冯维斗. 脑部乳酸供能的方式[J]. 生命的化学, 2010, 0(2) |
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| 作者姓名： | 王今越 王小虹 陈民盛 冯维斗 |
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| 作者单位： | 佛山大学体育学院;东北师范大学体育学院;深圳大学体育部;吉林省体育科研所; |
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| 基金项目： | 吉林省体育局课题基金(2007D11); 佛山科技学院2007年课题基金(20071206)资助 |
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| 摘 要： | 脑部存在星形胶质细胞-神经元的乳酸穿梭方式供能。单羧酸转运蛋白2(monocarboxylate transporter 2,MCT2)和MCT4的细胞特异性分布与乳酸穿梭的方向存在密切联系。MCT2和MCT4分别集中于神经元突触后膜致密区与星形胶质细胞终足膜,可能有利于N-甲基-D-天冬氨酸(N-methyl-D-asparticacid,NMDA)受体抑制的解除及循环中乳酸穿越血脑屏障。神经元和星形胶质细胞均能利用乳酸或血糖作为氧化底物。神经元中,乳酸是比血糖更为优势的氧化底物,其原因有待研究。脑部乳酸不仅来源于血糖酵解,还来源于血液循环中的乳酸及星形胶质细胞的糖原酵解。
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| 关 键 词： | 脑 乳酸 供能 |
Astrocyte-neuron lactate shuttle for energy supply in brain |
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| Jin-Yue Wang,Xiao-Hong Wang,Min-Sheng Chen,Wei-Dou Feng. Astrocyte-neuron lactate shuttle for energy supply in brain[J]. Chemistry of Life, 2010, 0(2) |
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| Authors: | Jin-Yue Wang Xiao-Hong Wang Min-Sheng Chen Wei-Dou Feng |
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| Affiliation: | Jin-Yue Wang1,Xiao-Hong Wang2,Min-Sheng Chen3,Wei-Dou Feng4 1 Department of Foshan University,Foshan 528000,China,2 Department of North east Normal University,Changchun 130026,3 Department of Shenzhen University,Shenzhen 518060,4 Department of Jilin sport scientific research institute,Changchun 130022 |
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| Abstract: | There is an astrocyte-neuron lactate shuttle in the brain.Cell-specific distribution of MCT2 and MCT4 are in close relationship with the direction of lactate shuttle.The concentrated distribution of MCT2 and MCT4 in astrocyte postsynaptic dense regions and the endfoot membrane possibly contributes to the removal of inhibition on NMDA receptor and the pass of lactate through blood-brain barrier from blood circulation.Both neurons and astrocytes can use lactate and glucose as oxidizing fuels.The reason that i... |
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| Keywords: | brain lactate energy supply |
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