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Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)
Authors:Balbo Michelle  Barel Monique  Lottin-Divoux Séverine  Jean Didier  Frade Raymond
Affiliation:INSERM U.672 (ex U.354), Immunochimie des Régulations Cellulaires et des Interactions Virales, Batiment G8, Campus 1, Génopole d'Evry, 5 rue Henri Desbruères, 91030, EVRY Cedex, France.
Abstract:Human cell lines are often infected by mycoplama strains. We have demonstrated that when infected by Mycoplasma fermentans, human B lymphoma cell proliferation increased strongly. These infected B cells expressed a p45 kDa protein which interacted with the intracellular domain of CD21, the EBV/C3d receptor. p45 analysis demonstrated that this is a new gene which encodes an elongation factor originating from Mycoplasma fermentans. p45 interaction with CD21 was specific, there being no interaction with CD19. This is the first demonstration that Mycoplasma fermentans, in infecting human B cells, generates a p45 Mycoplasma component that interacts with CD21, which is involved in B cell proliferation.
Keywords:Mycoplasma infection    B lymphocyte proliferation    CD21
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