| ADAM33基因研究进展 |
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| 引用本文： | 苏智广,文富强,冯玉麟.ADAM33基因研究进展[J].遗传,2005,27(4):636-640. |
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| 作者姓名： | 苏智广 文富强 冯玉麟 |
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| 作者单位： | 四川大学华西医院呼吸病学研究室, 成都 610041 |
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| 摘 要： | ADAM33基因定位于20号染色体短臂20p13，属于ADAM基因超家族。ADAM基因超家族编码的蛋白质具有金属蛋白酶活性，这种活性与多种疾病的发生相关。在不同人群中的病例-对照及家系研究提示ADAM33基因可作为哮喘的候选基因，其抑制剂有望用于哮喘病的治疗。
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| 关 键 词： | ADAM基因家族 ADAM33基因 哮喘 |
| 文章编号： | 0253-9772(2005)04-0636-05 |
| 收稿时间： | 2004-03-17 |
| 修稿时间： | 2004年3月17日 |
Progress in Study of ADAM33 Gene |
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| Su Zhi-guang,Wen Fu-qiang,FENG Yu-Lin.Progress in Study of ADAM33 Gene[J].Hereditas,2005,27(4):636-640. |
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| Authors: | Su Zhi-guang Wen Fu-qiang FENG Yu-Lin |
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| Institution: | Laboratory of Pulmonary Medicine, West China Hospital, Sichuan University, Chengdu 610041, China |
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| Abstract: | A disintegrin and metalloprotease-encoding gene (ADAM) 33, located on the short arm of chromosome 20 (20p13), was recently identified through a genome-wide scan for asthma. It is a new member of a family of genes encoding a group of the metalloproteinase superfamily called the ADAM family. The proteolytic activity of the ADAMs plays an important role in the healthy and disease states. The identification of ADAM33 as a candidate gene for asthma may provide a newly therapeutic target for this disease. |
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| Keywords: | ADAM33 gene ADAM family asthma |
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