The evolving role of 3D domain swapping in proteins |
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| Authors: | Bennett Melanie J Eisenberg David |
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| Affiliation: | Howard Hughes Medical Institute, Departments of Chemistry and Biochemistry and Biological Chemistry, University of California, Los Angeles, CA 90095 USA |
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| Abstract: | 3D domain swapping is increasingly implicated in amyloidosis but also has potential functional advantages in soluble proteins. Indeed, the structure of an NF-κB p50 mutant (Chirgadze et al., 2004) demonstrates that 3D domain swapping can rescue function after a destabilizing mutation. This work has wider implications for the evolution of protein oligomers. |
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