Resistance and augmentation of innate immunity in mice exposed to starvation |
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Authors: | Jiwei Shen Hongwei Ren Mayumi Watanabe Masashi Inoue Toru Abo |
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Affiliation: | a Department of Immunology, Niigata University School of Medicine, Niigata 951-8510, Japan b Department of Medical Technology, Niigata University School of Health Sciences, Niigata 951-8518, Japan c Heilongjiang Provincial Hospital, 82 Zhong Shan Road, Harbing City Heilongjiang Prov. 150036, China |
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Abstract: | Mice were exposed to starvation for 3 days. Body temperature and various parameters were examined. By starvation, body temperature, blood glucose and ACTH decreased, especially on days 2 and 3. The level of corticosterone increased at this time. On the other hand, the number of lymphocytes yielded by the liver, spleen and thymus decreased from day 1 to 3. The change of the distribution of lymphocyte subsets was unique because NK, NKT and extrathymic T cells were stress-resistant in the liver. Conventional T and B cells were stress-sensitive. Reflecting the increased proportion of NK and NKT cells, NK and NKT activities were augmented. The increased proportion of NKT cells produced both IFNγ and IL-4 (Th0-type profile). The proportion and some functions of granulocytes and macrophages increased on Day 1 after starvation. These results suggest that starvation has a potential to increase the functions of unconventional lymphocytes and myeloid cells. |
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Keywords: | Starvation Innate immunity NK cells NKT cells Extrathymic T cells Myeloid cells |
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