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Age-associated parallel increase of Foxp3CD4 regulatory and CD44CD4 memory T cells in SJL/J mice
Authors:Guang-Ming Han  Samithamby Jeyaseelan  Ji-Ming Feng
Institution:a Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University [LSU], Baton Rouge, LA 70803, USA
b College of Life Sciences, Hebei Normal University, PR China
c Department of Pathobiological Sciences and Center for Experimental Infectious Disease Research, LSU, Baton Rouge, LA 70803, USA
d Section of Pulmonary and Critical Care Medicine, Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA
Abstract:Effector/memory T cells (Tem) are required to maintain successful immunity, while regulatory T cells (Treg) are required to prevent excessive/uncontrolled inflammation and/or autoimmunity. Although both Tem and Treg cells are increased during aging, the relationship between the increased proportion of Foxp3+ Treg cells and CD44+ Tem cells with aging is not clearly understood. We found in this report that Foxp3+ Treg cells are increased in parallel with CD44+ Tem cells in SJL/J mice with aging, and that all Foxp3+ Treg cells are of CD44+ Tem phenotype, suggesting that the increased Foxp3+ Treg cells originated from the expanded pool of CD44+ Tem cells with aging. Our in vitro kinetic studies further suggested that Foxp3+ Treg cells are converted through the CD44+ stage. Furthermore, we observed that although the balance between Foxp3+ Treg and CD44+Foxp3 Tem cells remained with aging, the aged mice have higher ratios of both Tem and Treg cells vs. naïve T cells resulting in the “shrunken” naïve T cell pools. Our results suggest that an age-associated imbalance of T cell repertoire is a mechanism that contributes to spontaneous occurrence of Hodgkin’s-like lymphoma in aged SJL/J mice.
Keywords:Regulatory T cell  Effector/memory T cell  Foxp3  Aging
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