The Role of ClpP in Protein Expression of <Emphasis Type="Italic">Streptococcus pneumoniae</Emphasis> |
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Authors: | Qun?Zhang Yuanshuai?Huang Hong?Wang Wenchun?Xu Lan?Liu Yibing?Yin Email author" target="_blank">Xuemei?ZhangEmail author |
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Institution: | (1) Clinical Laboratories Center, Affiliated Children’s Hospital, Chongqing Medical University, Chongqing, 400016, People’s Republic of China;(2) Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; |
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Abstract: | Previous reports suggest that ClpP proteolytic activity is important not only for cell physiology but also for regulation
of virulence properties of Streptococcus pneumoniae (S. pneumoniae). In order to get a more comprehensive picture of the role of ClpP protease on protein expression in S. pneumoniae D39 and how it relates to physiology and virulence, a clpP mutant strain was constructed in S. pneumoniae D39, and global proteome expression was studied by 2-dimensional electrophoresis and matrix-assisted laser desorption-ionization-time
of flight mass spectrometry. We report here that clpP deletion affects the expression of proteins which are involved in the general stress response, nucleotide metabolism, energy
metabolism, and proteins metabolism. These provide clues for understanding the role of ClpP in the physiology and pathogenesis
of pneumococcus. |
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