OmpR May Regulate the Putative YehU/YehT Two-Component System in <Emphasis Type="Italic">Salmonella enterica</Emphasis> serovar Typhi Under Hypotonic Growth Condition |
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Authors: | Haifang?Zhang Hong?Du Xiaolan?Ji Bin?Ni Linxiang?Mao Shungao?Xu Xiumei?Sheng Huaxi?Xu Email author" target="_blank">Xinxiang?HuangEmail author |
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Institution: | (1) Department of Biochemistry and Molecular Biology, School of Medical Technology, Jiangsu University, Zhenjiang, 212013, Jiangsu, China; |
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Abstract: | Decreased expression (twofold) of a putative yehUTS operon of which yehUT encodes a putative YehU/YehT two-component system in the ompR mutant from Salmonella enterica serovar Typhi (S. Typhi) GIFU10007 under hypotonic growth condition was observed by qRT-PCR. Purified recombinant protein OmpRHis6 of GIFU10007 was shown to bind the upstream region of the yehU gene by the gel-shift assay. In addition, the yehT deletion mutant (ΔyehT) displayed differential expression (twofold or higher) of 26 genes under the condition by the DNA microarray analysis. Altogether,
OmpR might regulate the YehUT system in S. Typhi under hypotonic growth condition. |
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