Estimation of the microcirculation state in cerebrovascular disorders using laser doppler flowmetry data and hemorheological parameters |
| |
Authors: | I A Tikhomirova S G Mikhailova S V Lychenko A O Oslyakova |
| |
Institution: | 1.Ushinskii State Pedagogical University,Yaroslavl,Russia;2.Ministry of Health and Social Development,Yaroslavl State Medical Academy,Yaroslavl,Russia |
| |
Abstract: | The microcirculation state was assessed in the group of patients with ischemic stroke (n = 30) and the control group of healthy individuals (n = 27) using laser Doppler flowmetry and the wavelet analysis of the amplitude-frequency range of microvascular blood flow
oscillations combined with absorption spectroscopy. The hemorheological parameters (blood and plasma viscosity, the degree
of red blood cell aggregability and deformability) were assessed in both groups, as were their correlations with the microcirculation
parameters. Decreased tissue perfusion (by 25%) and specific oxygen consumption (by 21%) were revealed in a cerebrovascular
accident. Changes in the tone-forming regulatory mechanisms of microcirculation of vasodilating nature (decreased microvascular
tone, activation of the secretory function of endothelium) may be regarded as a compensatory reaction aimed at maintaining
the blood supply of organs and tissues in stroke. The blood viscosity increase in patients due to the plasma viscosity increase
and increased red blood cell aggregability and their decreased deformability cause the blood flow to slow down and the wall
shear stress to increase, which activates the endothelial secretory function and vasodilation of microvessels. Correlation
between the rheological parameters and the passive (respiratory and cardiac) rhythm amplitudes was observed in the control
group. In patients, the hemorheological parameters were correlated with the characteristics of the active factors of microvascular
blood flow modulation (endothelial, neurogenic, and myogenic), which confirms the role of changed blood properties and regulatory
tone-forming mechanisms in the maintenance of tissue perfusion in cerbrovascular accidents. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|