Tissue engineering strategies to bioengineer the ageing skin phenotype in vitro |
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Authors: | Lydia Costello Teresa Dicolandrea Ryan Tasseff Robert Isfort Charlie Bascom Thomas von Zglinicki Stefan Przyborski |
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Institution: | 1. Department of Biosciences, Durham University, Durham UK ; 2. Procter and Gamble, Mason Business Center, Cincinnati Ohio, USA ; 3. Institute for Cell and Molecular Sciences, Newcastle University, Newcastle Upon Tyne UK ; 4. Reprocell Europe, Glasgow, Durham UK |
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Abstract: | Human skin ageing is a complex and heterogeneous process, which is influenced by genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic stressors. In the current world ageing demographic, there is a requirement for a bioengineered ageing skin model, to further the understanding of the intricate molecular mechanisms of skin ageing, and provide a distinct and biologically relevant platform for testing actives and formulations. There have been many recent advances in the development of skin models that recapitulate aspects of the ageing phenotype in vitro. This review encompasses the features of skin ageing, the molecular mechanisms that drive the ageing phenotype, and tissue engineering strategies that have been utilised to bioengineer ageing skin in vitro. |
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Keywords: | ageing bioengineered tissue human in vitro molecular biology of aging skin |
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