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Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors |
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| Authors: | Li Hongmei Asberom Theodros Bara Thomas A Clader John W Greenlee William J Josien Hubert B McBriar Mark D Nomeir Amin Pissarnitski Dmitri A Rajagopalan Murali Xu Ruo Zhao Zhiqiang Song Lixin Zhang Lili |
| Institution: | Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. hongmei.li@spcorp.cpm |
| Abstract: | Development of cis-2,4,6-trisubstituted piperidine N-arylsulfonamides as gamma-secretase inhibitors for the potential treatment of Alzheimer's disease (AD) is reported. |
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