Study of novel rosin-based biomaterials for pharmaceutical coating |
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Authors: | Fulzele Suniket V Satturwar Prashant M Dorle Avinash K |
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Institution: | (1) Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, 440010 Nagpur, India |
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Abstract: | The film forming and coating properties of Glycerol ester of maleic rosin (GMR) and Pentaerythritol ester of maleic rosin
(PMR) were investigated. The 2 rosin-based biomaterials were initially characterized in terms of their physicochemical properties,
molecular weight (Mw), and glass transition temperature (Tg). Films were produced by solvent evaporation technique on a mercury
substrate. Dibutyl sebacate plasticized and nonplasticized films were characterized by mechanical (tensile zzzz strength,
percentage elongation, and Young's modulus), water vapor transmission (WVT), and moisture absorption parameters. Plasticization
was found to increase film elongation and decrease the Young's modulus, making the films more flexible and thereby reducing
the brittleness. Poor rates of WVT and percentage moisture absorption were demonstrated by various film formulations. Diclofenac
sodium-layered pellets coated with GMR and PMR film formulations showed sustained drug release for up to 10 hours. The release
rate was influenced by the extent of plasticization and coating level. The results obtained in the study demonstrate the utility
of novel rosin-based biomaterials for pharmaceutical coating and sustained-release drug delivery systems. |
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Keywords: | rosin film coating biomaterials pellets mechanical properties |
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