Induction of specific-locus and dominant lethal mutations in male mice by busulfan |
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Authors: | U H Ehling A Neuh?user-Klaus |
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Institution: | GSF-Institut für S?ugetiergenetik, Neuherberg, F.R.G. |
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Abstract: | The chemotherapeutic agent busulfan was tested for the induction of dominant lethal and specific-locus mutations in male mice. A dose of 5 mg/kg b.w. of busulfan induces dominant lethal mutations in spermatozoa. A dose of 20 mg/kg b.w. induces dominant lethal mutations in spermatozoa and spermatids. A total of 83,196 offspring were scored in the specific-locus experiments. Busulfan-induced specific-locus mutations were recovered in spermatozoa and spermatids, but not in spermatogonia. The sensitivity patterns for the induction of dominant lethal and specific-locus mutations by busulfan in germ cells of male mice are similar but not identical. |
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