Two new rotenoids from the roots of Millettia speciosa |
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| Institution: | 1. Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences & Peking Union Medical College, Wanning 571533, China;2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China;1. Department of Chemistry, University of Nairobi, P. O. Box 30197-00100, Nairobi, Kenya;2. Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, Potsdam, D-14415, Germany;4. Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany;5. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Stawdenger Weg 5, Mainz 55128, Germany;1. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany;2. Department of Chemistry, Middle Tennessee State University, P.O. Box 68, Murfreesboro, TN 37132, USA;3. Laboratory of Natural Products Chemistry, Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;4. Department of Biology, Middle Tennessee State University, P.O. Box 60, Murfreesboro, TN 37132, USA;1. Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), 35900, Tanjong Malim, Perak, Malaysia;2. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310, Skudai, Johor, Malaysia;3. Faculty of Applied Sciences, Universiti Teknologi MARA, Pasir Gudang Campus, Jalan Purnama, Bandar Seri Alam, 81750 Masai, Johor, Malaysia;4. Kulliyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200, Kuantan, Pahang, Malaysia;5. Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, United Kingdom;6. Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, ?lechtitel? 27, 78371, Olomouc, Czech Republic;1. Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya;2. Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI) – Walter Reed Project, P.O. Box 54 - 40100, Kisumu, Kenya;3. Institut für Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany;1. Key Laboratory on Luminescence and Real-Time Analysis (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China;2. Agriculture and Animal Husbandry College, Tibet University, Nyingchi, Tibet 860000, PR China;3. School of Life Sciences, Southwest University, Chongqing 400715, PR China |
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| Abstract: | Two new rotenoids, named millettiaosas A–B (1–2), together with four known compounds were isolated from the roots of Millettia speciosa. Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and HRESIMS. Evaluation of the two new compounds for cytotoxicity against four human cancer cell lines (MCF-7, HCT-116, A549 and HepG-2) showed moderate activities (10 μM < IC50 < 26 μM). |
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| Keywords: | Rotenoid Cytotoxicity |
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