Neuroprotective metabolites from the endophytic fungus Penicillium citrinum of the mangrove Bruguiera gymnorrhiza |
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| Institution: | 1. Collaborative Innovation Center of Water Quality Safety and Protection in Pearl River Delta, Guangzhou University, Guangzhou 510006, China;3. College of Life Science, South China Normal University, Guangzhou 510631, China;4. School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5005, Australia;5. State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;6. School of Life Sciences, Guangzhou University, Guangzhou 510006, China;7. School of Geographical Sciences, Guangzhou University, Guangzhou 510006, China;1. Collaborative Innovation Center of Water Quality Safety and Protection in Pearl River Delta, Guangzhou University, Guangzhou 510006, China;3. Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, China;4. School of Biological Sciences, The University of Adelaide, Adelaide, South Australia, Australia;5. School of Environmental Science and Engineering/Research Centre of Wetland Science, Sun Yat-Sen University, Guangzhou 510275, China;6. China National Analytical Center (Guangzhou), Guangzhou 510070, China;7. School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China;8. School of Life Sciences, Guangzhou University, Guangzhou 510006, China |
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| Abstract: | Two new compounds, named as (Z)-7,4′-dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside (1), and (1S,3R,4S)-1-(4′-hydroxyl-phenyl)-3,4-dihydro-3,4,5-trimethyl-1H-2-benzopyran-6,8-diol (2), were isolated from the endophytic fungus Penicillium citrinum of Bruguiera gymnorrhiza. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 1 exhibited potent neuroprotective activity in 1-methyl-4-phenylpyridinium-induced oxidative damage in PC12 cells. |
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| Keywords: | Endophytic fungus Neuroprotective activity |
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