Triterpenoid saponins from Aesculus sylvatica W. Bartram |
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| Institution: | 1. National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962-6109, USA;2. College of Life Science, Northeast Forestry University, 26 Hexing Road, Harbin, Heilongjiang 150040, China;1. Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Qiuyang Road 1#, Fuzhou 350122, PR China;2. School of Pharmacy, Second Military Medical University, Guohe Road 325#, Shanghai 200433, PR China;3. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Fengyang Road 415#, Shanghai 200003, PR China;4. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cailun Road 1200#, Shanghai 201203, PR China;1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;2. Department of Geology, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan;3. Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan;4. Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan;5. Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan;6. Department of Biotechnology, Sardar Bahadur Khan Women University, Quetta, Pakistan;1. School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, Anhui, PR China;2. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, PR China;1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China;2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China |
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| Abstract: | 16 triterpenoid saponins including two new compounds were isolated from the seeds of A esculus sylvatica W. Bartram. The two new saponins were assigned as 3-O-β-D-glucopyranosyl-(1 → 2)]-α-L-arabinofuranosyl-(1 → 3)-β-D-glucuronopyranosyl-21,22-O-ditigloyl-3β,16α,21β,22α,24,28 hexahydroxyolean-12-ene (aesculioside S1, 1) and 3-O-β-D-glucopyranosyl-(1 → 2)]-α-L-arabinofuranosyl-(1 → 3)-β-D-glucuronopyranosyl-21-O-tigloyl-22-O-angeloyl 3β,16α,21β,22α,24,28-hexahydroxyolean-12-ene (aesculioside S2, 2). Aesculioside S1 and S2 displayed moderate cytotoxicity against human non-small cell lung cancer cells (A549) and prostate cancer cells (PC3) (GI50 ranged from 8.7 to 18.2 μM). The structural analysis of the saponins isolated from Aesculus supports the taxonomic placement of A. sylvatica under the section Pavia of Aesculus genus. |
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| Keywords: | Painted buckeye Triterpenoid saponins Cytotoxicity Chemotaxonomy |
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