Antifungal metabolites from the rhizospheric Penicillium sp. YIM PH 30003 associated with Panax notoginseng |
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| Institution: | 1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People''s Republic of China;2. Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, People''s Republic of China;1. School of Pharmacy, Nantong University, Nantong 226001, China;2. School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China;1. Shandong Province Medical and Health Key Laboratory of Natural Medicines, Pharmacy Department, Binzhou Medical University, Gang Cheng East Street 346, Yantai 264003, China;2. Yantai Yu Huang Ding Hospital, Yu East Road 20, Yantai 264000, China;3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. Department of Organic Chemistry, University of Science, National University—Ho Chi Minh City, 227 Nguyen Van Cu Str., Dist. 5, 748355 Ho Chi Minh City, Vietnam;2. Department of Chemical–Food Technology, University of Technical Education—Ho Chi Minh City, 1 Vo Van Ngan Str., Thu Duc Dist., 720214 Ho Chi Minh City, Vietnam;3. Department of Chemistry, Ho Chi Minh City University of Pedagogy, 280 An Duong Vuong Street, District 5, 748342 Ho Chi Minh City, Vietnam;4. Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, Vietnam |
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| Abstract: | Two new N-benzoylamino acids, peniginseng A-B (1–2), and two new fatty acids, peniciginseng A-B (5–6), were isolated during the fermentation of Penicillium sp. YIM PH30003, an endophytic fungus associated with Panax notoginseng (Burk.) F.H. Chen. Their structures were assigned based on a combination of 1D and 2D NMR and mass spectral data. The N-benzoylamino acids (1–4) might share similar biosynthetic pathways with the rare siderophore pistillarin. Compounds 1–10 showed antifungal activities (MICs 16–128 μg/mL) against Fusarium solani, the pathogenic fungus of P. notoginseng. |
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| Keywords: | N-Benzoylamino acid Fatty acid Sesquiterpene quinine Antifungal activity |
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