Antimycobacterial dihydronaphthalenone from the endophytic fungus Nodulisporium sp. of Antidesma ghaesembilla |
| |
| Institution: | 1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand;2. Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Bangkok 10400, Thailand;3. Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand;4. Department of Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10300, Thailand;1. Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan;2. Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan;3. Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;2. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;3. Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China;4. New Technology Center of Chemical Pharmaceutical Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry, Shanghai 200437, China;5. Jiangxi Qingfeng Pharmaceutical Corporation, Ganzhou 341000, China;1. Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, P. R. China;2. Reyoung Pharmaceutical Co., Ltd, No. 44 Cultural West Road, Jinan 250012, P. R. China;1. Joint Reconstruction Unit, UCL Institute of Orthopaedics and Musculoskeletal Science and the Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, United Kingdom;2. University of Western Sydney, Parramatta, New South Wales, Australia;3. Clinical Epidemiology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom;1. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;2. Jiangzhong Pharmaceutical Group Company Limited, Nanchang 330096, China;3. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;4. Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan |
| |
| Abstract: | Two new dihydronaphthalenones (1, 2) with four known compounds (3–6) were isolated as secondary metabolites of the endophytic fungus Nodulisporium sp. from Antidesma ghaesembilla. Their chemical structures were established based on 1D and 2D NMR spectroscopic data and HR-ESI–MS analyses. The relative configuration of 2 was confirmed by single crystal X-ray crystallographic analysis. A new isofuranonaphthalenone 2 displayed antimycobacterial and antimalarial activities with IC50 values of 3.125 and 11.3 μg/mL, respectively. |
| |
| Keywords: | Dihydronaphthalenones Antimycobacterial Antimalarial |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
