Phytochemical study of Capraria biflora L. aerial parts (Scrophulariaceae) from Martinique island (French West Indies) |
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| Institution: | 1. Laboratoire de Pharmacognosie et de Chimie des Substances Naturelles-UMR/CNRS 8638 COMETE, Université Paris Descartes, Faculté de Pharmacie de Paris, 75270 Paris cedex, France;2. Pôle Agroalimentaire Régional de Martinique, Impasse Petit-Morne—N°375 97232 Lamentin, Martinique, France;3. Laboratoire Ecosystème Intestinal, Probiotiques, Antibiotiques-EA 4065, Université Paris Descartes, Faculté de Pharmacie de Paris, 75270 Paris cedex, France;1. Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, P. R. China;2. Reyoung Pharmaceutical Co., Ltd, No. 44 Cultural West Road, Jinan 250012, P. R. China;1. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China;2. School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;1. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;1. Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China;2. College of Life Sciences, Northwest A&F University, Shaanxi 712100, PR China;3. Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China |
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| Abstract: | Aerial parts of Capraria biflora L. were collected in Martinique (French West Indies) and extracted by methanol. Two original chlorinated iridoids, 3-hydroxymyopochlorin (1) and 5-hydroxyglutinoside (2) were isolated by CPC (centrifugal partition chromatography) and characterized from the extract together with five known iridoid glycosides (3–7), two flavonoid glucuronides (8–9) and the phenylethanoid glycoside verbascoside (10). The structure of these compounds together with their relative configuration was established by spectroscopic data including in particular 1D and 2D NMR experiments (HSQC, HMBC, NOESY) and HRESIMS. Preliminary antibacterial evaluation of 1, 2 and 3 against a panel of Gram-positive and Gram-negative strains has been performed. |
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| Keywords: | Scrophulariaceae Iridoïds Flavonoids Antibacterial activity |
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