Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce |
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| Affiliation: | 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;2. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;3. Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;4. Key Laboratory of Marine Bioactive Substances, First Institute of Oceanography, State Oceanic Administration Republic of China, Qingdao 266061, China;1. National Institutes of Health—NIRT—International Center for Excellence in Research, Chennai, India;2. National Institute for Research in Tuberculosis, Chennai, India;3. Bioinformatics and Computational Biosciences Branch, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA;4. Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA;1. Department of Chemistry, University of Iowa, Iowa City, IA 52242, United States;2. Bacterial Foodborne Pathogens & Mycology Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDA, Peoria, IL 61604, United States;1. CNRS, Institut de Chimie des Substances Naturelles, 1 Avenue de la Terrasse, 91198 Gif-Sur-Yvette Cedex, France;2. Laboratoire Shigeta, 62 boulevard Davout, 75020 Paris, France;3. CNRS/Sorbonne Universités, LBBM, Observatoire Océanologique, 66650 Banyuls-sur-mer, France;1. Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, China;2. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China;3. Yuxi Research Center for Eco-environmental Sciences on Plateau Lakes, Yuxi Normal University, Yuxi 653100, China;1. Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;2. Department of Microbiology and Natural Products Research Center of Excellence, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;3. National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand |
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| Abstract: | Two new prenylated phenols vaccinol H (1) and vaccinol I (2), together with three known phenols derivatives 3–5, one glyceride derivative 6, and ergosterol 7 were isolated from endogenous Pestalotiopsis vaccinii (cgmcc3.9199) of mangrove plant Kandelia candel (L.) Druce (Rhizophoraceae). The new structures of 1 and 2 were determined by spectroscopic analyses and circular dichroism (CD) spectra. Most of the isolated compounds (2–6) were tested for their antiviral (EV71), cytotoxic, anti-tuberculosis, and anti-inflammatory effects. Among these compounds, compound 2 exhibited potent COX-2 inhibitory activity with an IC50 value of 16.8 μM. |
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| Keywords: | Structure elucidation COX-2 inhibitory activity |
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