Polyketides from the marine mangrove-derived fungus Aspergillus ochraceus MA-15 and their activity against aquatic pathogenic bacteria |
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| Institution: | 1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;2. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;3. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;5. South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, China |
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| Abstract: | Three new polyketides, namely, asperochrins A–C (1–3), along with 12 known related derivatives (4–15), were isolated from Aspergillus ochraceus MA-15, a fungus obtained from the rhizospheric soil of marine mangrove plant Bruguiera gymnorrhiza. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute configurations of the new compounds were determined by CD experiments and modified Mosher's method. The X-ray crystallographic experiment of compound 4 disclosed its racemic nature as (±)-botryoisocoumarin A for the first time. The brine shrimp lethality and antibacterial activity of compounds 1–15 were evaluated. Compounds 1, 5, 6, 9, 11, and 15 showed inhibitory activity against aquatic pathogenic bacterial Aeromonas hydrophila, Vibrio anguillarum, and Vibrio harveyi. |
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| Keywords: | Mangrove rhizospheric fungus Secondary metabolites Polyketide derivatives Antibacterial activity |
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