Two new butanolides from the roots of Litsea acuminata |
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| Institution: | 1. Faculty of Pharmacy, Meijo University, Yagoto, Tempaku-ku, Nagoya 468-8503, Japan;2. Department of Oral Biology, Asahi University School of Dentistry, 1851-Hozumi, Mizuho, Gifu 501-0296, Japan;3. Botanical Gardens, Graduate School of Science, The University of Tokyo, Hakusan, Bunkyo-ku, Tokyo 112-0001, Japan;4. Faculty of Pharmaceutical Sciences, Setsunan University, Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan;5. Tanegashima Division, Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, 17007-2 Noma-Matsubarayama, Nakatate-cho, Kumage-gun, Kagoshima 891-3604, Japan;6. Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502–8585, Japan;1. College of Resource and Environment, Yuxi Normal University, Yuxi 653100, PR China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China;3. College of Resources and Environment, Southwest University, Chongqing 400716, PR China;1. Jiangsu Kanion Pharmaceutical Co. Ltd., 58 South Haichang Road, Lianyungang 222001, PR China;2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, PR China;3. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;1. School of Pharmacy, Shihezi University, Shihezi 832002, China;2. Xinjiang Academy of Forestry, Urumqi 830000, China;3. School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;2. Biotechnology Division, Guangdong Academy of Forestry, Guangzhou 510520, China;3. Guangdong Open Laboratory of Applied Microbiology, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, China;4. University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Two new butanolides, licunolides A (1) and B (2), were isolated from the roots of Litsea acuminata, together with three known compounds: isolancifolide (3), longifolin (4), and sesquirose furan (5). The structures of compounds 1 and 2 were determined by spectroscopic studies (IR, MS, 1D and 2D NMR) and chemical evidence. This is the first report of 4-hydroxy-5-methylbutanolides with a C10-side chain from a natural source. Longifolin (4) and sesquirose furan (5) showed a significant cytotoxicity against HeLa cell lines in vitro. |
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| Keywords: | Lauraceae Butanolides Licunolide A Licunolide B Cytotoxicity |
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