Flavonoids and other bioactive constituents from Ficus thonningii Blume (Moraceae) |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Science, TWAS Research Unit (TRU) of the University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon;2. Department of Chemistry, Higher Teachers’ Training College, University of Yaoundé 1, P.O. Box 47, Yaoundé, Cameroon;3. Department of Chemistry, Faculty of Science, University of Bamenda, P.O. Box 39, Bambili, Cameroon;4. ICCBS, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Pakistan;5. Pharmaceutical Research Centre of Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi 75280, Pakistan;6. Programme in Medicine, Faculty of Health Science, University of Buea, P.O. Box: 63, SW Region, Cameroon;7. Department of Chemistry, Higher Teachers’ Training College of Maroua, University of Maroua, P.O. Box 55, Maroua, Cameroon;1. Jiangsu Kanion Pharmaceutical Co. Ltd., 58 South Haichang Road, Lianyungang 222001, PR China;2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, PR China;3. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China;1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan;2. Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh;3. Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh;4. University of the Philippines Visayas Tacloban College, Tacloban City 6500, Philippines;1. ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;2. Laboratoire de Chimie Organique Biologique, 01 BPV 34 Abidjan 01, Université Félix-Houphouët Boigny d’Abidjan-Cocody, Cote d’Ivoire;3. ICMR-UMR CNRS 7312, Service Commun d’Analyses, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;1. Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, 25240 Erzurum, Turkey;2. Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey;3. Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey |
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| Abstract: | Continued interest in the chemistry of Ficus spp. led to the investigation of the figs and the roots of Ficus thonningii Blume. Two new flavonoids, thonningiol (1) and thonningiisoflavone (2) along with nineteen known compounds were isolated. β-Isoluteone (13) was isolated here for the first time from a natural source. Their structures were elucidated on the basis of spectroscopic evidence. Interestingly, thonningiisoflavone (2) and hydroxyalpinumisoflavone (21) showed strong DPPH radical scavenging activity with IC50 = 65.50 μM and 68.20 μM respectively compared to the standard BHA with IC50 = 44.20 μM. The methanolic extract of figs, taxifolin (14), conrauiflavonol (17) and shuterin (19) exhibited moderate antimicrobial activity against six micro-organisms with MIC below 1.5 mg/mL. |
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| Keywords: | Thonningiol Thonningiisoflavone Antioxidant activity Antimicrobial activity |
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