Two new alkaloids from Penicillium oxalicum EN-201, an endophytic fungus derived from the marine mangrove plant Rhizophora stylosa |
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| Affiliation: | 1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China;2. University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China;1. School of Biological Sciences, Nanyang Technological University, Singapore;2. Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón, Spain;1. China State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;2. School of Biological Science and Technology, University of Jinan, Jinan 250022, China;3. School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009, China;4. Syngenta Jealott''s Hill International Research Centre, Berkshire RG42 6EY, United Kingdom;1. Marine Drugs Research Center, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, PR China;2. Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, PR China;3. Department of Marine Sciences, Faculty of Sciences and Fishery Technology, Rajamangala University of Technology Srivijaya, Trang Campus, Sikao District, Trang Province 92150, Thailand;1. Ministry of Health, Mohayl Hospital, Asir Region, Abha 61412, Saudi Arabia;2. Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;3. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt;1. Key Laboratory of Tropical Marine Bio-resources and Ecology/RNAM Center for Marine Microbiology/Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China;2. Graduate School of the Chinese Academy of Sciences (University of Chinese Academy of Sciences), Beijing 100049, PR China;3. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Road, Guangzhou 510530, PR China |
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| Abstract: | Two new alkaloids including a new prenylated indole derivative possessing a piperidine moiety, penioxamide A (1), and a new decaturin analogue, 18-hydroxydecaturin B (2), were isolated and identified from Penicillium oxalicum EN-201, an endophytic fungus obtained from the inner tissue of the fresh leaves of marine mangrove plant Rhizophora stylosa. Their structures and absolute configurations were elucidated on the basis of the spectral data and CD analysis. Compound 1 bears the rare anti relative configuration in the bicyclo[2.2.2]diazaoctane ring, while compound 2 has a pyridinyl-α-pyrone substructure which is rare among natural products. Compounds 1 and 2 showed potent brine shrimp lethality with LD50 values of 5.6 and 2.3 μM, respectively. |
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| Keywords: | Marine mangrove Endophytic fungus Alkaloid Brine shrimp lethality |
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