Pyrazole alkaloids from watermelon (Citrullus lanatus) seeds |
| |
| Affiliation: | 1. Department of Chemistry, National Institute of Technology, Warangal, 506004, Telangana, India;2. Department of Biotechnology, National Institute of Technology, Warangal, 506004, Telangana, India;3. Environmental Monitoring & Exposure Assessment (Air) Laboratory, ICMR−NIREH, Bhopal, 462030, Madhya Pradesh, India;4. Molecular Modeling and Medicinal Chemistry Group, Department of Chemistry, University College of Science, Osmania University, Hyderabad, 500007, Telangana, India |
| |
| Abstract: | Three new compounds, i.e. 1-[2-(5-hydroxymethyl-1H-pyrrole-2-carbaldehyde-1-yl)ethyl]-1H-pyrazole (1), 1-({[5-(α-d-galactopyranosyloxy)methyl]-1H-pyrrole-2-carbaldehyde-1-yl}-ethyl)-1H-pyrazole (2), and (4-hydroxyphenyl)methanol 4-[β-d-apiofuranosyl(1→2)-O-β-d-glucopyranoside] (3), were isolated from an extract of watermelon seeds. Compounds 1 and 2 were pyrazole-alkaloids with a pyrrole ring. This is the first study to show compounds with pyrrole and pyrazole rings in a molecule isolated from natural products. In the evaluation for melanogenesis inhibitory, compound 1 exhibited modest inhibitory activity on melanogenesis without cytotoxicity. Meanwhile compound 2 showed some inhibitory activity accompanied by some cytotoxicity. |
| |
| Keywords: | Alkaloid Glycoside Inhibitory activity on melanogenesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
