New biphenyl derivatives from the leaves of Nicotiana tabacum and their cytotoxic activity |
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| Affiliation: | 1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, PR China;2. Technology Center, China Tobacco Yunnan Industry Company (Ltd.), Kunming 650000, PR China;3. School of Ethnic Medicine, Yunnan Minzu University, Kunming 650031, PR China;1. Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;1. Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea;2. College of Pharmacy, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-gu, Seoul 120-808, Republic of Korea;3. Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeon-ju, Republic of Korea;4. College of Pharmacy, The Catholic University of Korea, Bucheon, Republic of Korea;5. College of Pharmacy, Institute of Pharmaceutical Sciences, Hanyang University, Ansan, Gyeonggido 426-791, Republic of Korea;1. The Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, PR China;2. Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China;1. HUS Helsinki Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Finland;2. Clinic of Gastroenterology, Helsinki University Hospital, Helsinki, Finland;3. Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;2. Department of Geology, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan;3. Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan;4. Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan;5. Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan;6. Department of Biotechnology, Sardar Bahadur Khan Women University, Quetta, Pakistan |
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| Abstract: | With the aim of searching for new bioactive metabolites from medicinal plants, three new biphenyls, tababiphenyls G–I (1–3), together with four known ones (4–7) were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by extensive NMR and MS spectroscopic analyses. All the isolated compounds were evaluated for their cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human cancer cell lines, and some of them showed moderate inhibitory activities against several human tumor cell lines with IC50 values ranging from 2.8 to 9.4 μM. |
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| Keywords: | Biphenyls Nicotiana tabacum Cytotoxic activity |
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