Biphenyl derivatives from the twigs of Garcinia bracteata and their biological activities |
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| Institution: | 1. College of Resource and Environment, Yuxi Normal University, Yuxi 653100, PR China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China;3. College of Resources and Environment, Southwest University, Chongqing 400716, PR China;1. School of Pharmacy, Shihezi University, Shihezi 832002, China;2. Xinjiang Academy of Forestry, Urumqi 830000, China;3. School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Department of Organic Chemistry, University of Science, National University—Ho Chi Minh City, 227 Nguyen Van Cu Str., Dist. 5, 748355 Ho Chi Minh City, Vietnam;2. Department of Chemical–Food Technology, University of Technical Education—Ho Chi Minh City, 1 Vo Van Ngan Str., Thu Duc Dist., 720214 Ho Chi Minh City, Vietnam;3. Department of Chemistry, Ho Chi Minh City University of Pedagogy, 280 An Duong Vuong Street, District 5, 748342 Ho Chi Minh City, Vietnam;4. Department of Chemistry, College of Natural Sciences, Can Tho University, Can Tho, Vietnam;1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;2. Biotechnology Division, Guangdong Academy of Forestry, Guangzhou 510520, China;3. Guangdong Open Laboratory of Applied Microbiology, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;1. ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;2. Laboratoire de Chimie Organique Biologique, 01 BPV 34 Abidjan 01, Université Félix-Houphouët Boigny d’Abidjan-Cocody, Cote d’Ivoire;3. ICMR-UMR CNRS 7312, Service Commun d’Analyses, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;1. Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Viet Nam;2. University of Technology, Vietnam National University, Ho Chi Minh City, Viet Nam |
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| Abstract: | Three new biphenyl derivatives, bractebiphenyls A–C (1–3), along with five known biphenyl derivatives (4–8) were isolated from the acetone extract of the twigs of Garcinia bracteata. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1–8 were evaluated. Compound 3 showed high anti-TMV activities with inhibition rates of 28.4%, which is close to that of Ningnanmycin (30.2%). Compounds 1–3, 6 and 8 were also tested for their cytotoxicities against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7), and 3 showed high cytotoxicities against A549 and PC3 cell with IC50 values of 3.6 and 2.7 μM, respectively. |
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| Keywords: | Biphenyl derivatives Anti-tobacco mosaic virus activity Cytotoxicity |
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