COX-2 inhibitors from the leaves of Pellacalyx saccardianus Scortech (Rhizophoraceae) |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia;2. Department of Pharmacognosy, College of Pharmacy, Kerbala University, Kerbala, Iraq;3. Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia;1. LISI Laboratory of Computer Science for Industrial Systems, Higher Institute of Documentation (ISD), Manouba University 2010, Tunisia;2. RIADI Research Laboratory, ENSI, Manouba University 2010, Tunisia;3. Emirates College of Technology, P.O. Box: 41009, Abu Dhabi, United Arab Emirates;4. Informatics Research Institute of Toulouse (IRIT), 02 Rue de Charles Camichel, 31071 Toulouse Cedex 7, France;5. Higher Institute of Informatics (ISI), Tunis El Manar University, 2080 Ariana, Tunisia;1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, Henan, PR China;2. School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou 450001, Henan, PR China;3. School of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou 450052, Henan, PR China;1. Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China;2. Jiangzhong Pharmaceutical Group Company Limited, Nanchang 330096, China;3. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;4. Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930-0194, Japan;1. Department of Chemistry, Faculty of Science, Kumamoto University, Kumamoto 860-8555, Japan;2. Department of Engineering Science, The University of Electro-Communications, Chofu, Tokyo 182-8585, Japan;3. Department of Chemistry, Faculty of Science, Okayama University, Tsushima-naka 3-1-1, Okayama 700-8530, Japan;4. Department of Chemistry, Chiba Institute of Technology, Shibazono 2-1-1, Narashino, Chiba 275-0023, Japan;5. Dipartimento di Farmacià, Universita degli Studi “G.D’Annunzio”, I-66100 Chieti, Italy;1. Hasselt University, Institute for Materials Research IMO, Wetenschapspark 1, B-3590 Diepenbeek, Belgium;2. Photonics Research Group, Department of Information Technology, Ghent University – INTEC, Sint-Pietersnieuwstraat 41, B-9000 Gent, Belgium;3. Linköping University, Department of Physics, Chemistry and Biology, S-581 83 Linköping, Sweden;4. Aachen University of Applied Sciences, Institute of Nano-and Biotechnologies, Heinrich-Mußmann-Straße 1, D-52428 Jülich, Germany;5. Hasselt University, Biomedical Research Institute BIOMED, Agoralaan, B-3590 Diepenbeek, Belgium;6. IMEC vzw, IMOMEC, Wetenschapspark 1, B-3590 Diepenbeek, Belgium;7. Koç University, Microphotonics Research Laboratory, Department of Physics, Rumelifeneri Yolu, Sarıyer, Istanbul 34450, Turkey |
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| Abstract: | Phytochemicals and anti-inflammatory activity were investigated in the leaves of Pellacalyx saccardianus from the Rhizophoraceae family. The powdered leaves were extracted using methanol in a soxhlet extractor. Purification of the methanol extract yielded two new compounds, (3S)(6R)-3-(4′-hydroxybenzyl)-6-(6″-hydroxyphenethyl)-2,2-dimethyl-piperidin-4-one and 1,2-O-(1-methylethylidene)fucoside, together with six known compounds, β-amyrin palmitate, squalene, 24-ethylcholesta-5,22,25-trien-3β-ol, 5R-hydroxy-1,7-bis(5-hydroxyphenyl)heptan-3-one, 1,7-bis(4-hydroxyphenyl)hept-4-en-3-one and methyl-l-fucoside. An anti-inflammatory assay using COX-2 revealed that β-amyrin palmitate possessed the highest inhibitory effect (96.8%) at the lowest concentration (0.01 μM), which was higher than that of the positive controls, resveratrol (90.2%, 0.01 μM) and indomethacin (79.20%, 100 μM). This is the first report on the isolation of phytochemicals from the leaves of P. saccardianus and their anti-inflammatory activity. |
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| Keywords: | Rhizophoraceae Diarylheptanoid alkaloid Phytochemicals Anti-inflammatory activity COX-2 |
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