Lemairones A and B: Two new antibacterial tetraflavonoids from the leaves of Zanthoxylum lemairei (Rutaceae) |
| |
| Institution: | 1. Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. Food Science and Nutrition, Department of Chemistry, Carleton University, Ottawa, ON, Canada;4. Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaounde, Cameroon;5. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle (Saale), Germany;1. Tropical Infectious Diseases Research and Education Centre (TIDREC), University of Malaya, Kuala Lumpur, 50603, Malaysia;2. Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia;3. Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia;4. The National Office in Southern Region, Ministry of Science and Technology, Government of Vietnam, No 31, Han Thuyen street, District 1, Ho Chi Minh city, Viet Nam;1. Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China;2. School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China;1. National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962-6109, USA;2. College of Life Science, Northeast Forestry University, 26 Hexing Road, Harbin, Heilongjiang 150040, China;1. Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China |
| |
| Abstract: | Zanthoxylum lemairei is widely used in African folk medicine for its pharmacological relevance. Chemical investigation of the ethanol extract from the leaves of this plant lead to the isolation of two new tetraflavonoids, lemairones A (1) and B (2), along with three known compounds, lupeol, sitosterol, and sitosterol 3-O-β-d-glucopyranoside. The antibacterial screening of the leaves of this plant, characterization of compounds 1 and 2, and their antibacterial activity are reported for the first time. The isolation of the compounds was performed using different chromatographic methods while their structures were elucidated by spectroscopic techniques including MS and NMR, and by comparison of data with those of similar flavonoids reported in the literature. The isolated compounds and the crude extract were tested against ten Gram negative multi-resistance bacterial strains including clinical isolates using a broth dilution method. The crude ethanol extract showed weak activity against the tested bacteria strains with a minimal inhibitory concentration (MIC) ranging from 512 to 1024 μg/mL. Among the isolated metabolites, only the new tetraflavonoids were tested. Lemairone A displayed weak activity while lemairone B had moderate activity against the resistant Escherichia coli AG100 with MIC values of 128 μg/mL and 64 μg/mL respectively. In addition, both molecules displayed weak activity against Klebsiella pneumoniae KP55 (MIC 128 μg/mL). |
| |
| Keywords: | Tetraflavonoids Lemairones Antibacterial |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
