Pregnane alkaloids from Sarcococca ruscifolia and their cytotoxic activity |
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| Institution: | 1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China;2. Chemical Biology Center, Lishui Institute of Agricultural Sciences, Lishui, Zhejiang 323000, China;3. Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, China;4. School of Pharmacy, Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou 550002, China;1. Institute for Agricultural and Fisheries Research (ILVO), Plant Sciences Unit, Applied Genetics and Breeding, Caritasstraat 21, 9090 Melle, Belgium;2. Herplant BVBA, Lilsedijk 80, 2340 Beerse, Belgium;1. Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;2. Department of Geology, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan;3. Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan;4. Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan;5. Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan;6. Department of Biotechnology, Sardar Bahadur Khan Women University, Quetta, Pakistan;1. Taihe hospital affiliated with Hubei University of Medicine, 32 South Renmin Road, Shiyan, Hubei, China;2. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, The University of Houston, 1441 Moursund Street, Houston, TX, 77030, USA;1. The Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, PR China;2. Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China |
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| Abstract: | Six pregnane alkaloids were isolated from the root of Sarcococca ruscifolia. The structures of three new alkaloids, namely, sarcorucinine E–G (1–3), were elucidated using spectroscopic methods, while three known alkaloids, namely, epipachysamine D, pachysamine M, and sarcovagine D, were identified by comparing their spectral data with those of the compounds reported earlier. All compounds were evaluated for their inhibitory activities against multiple types of cancer cells. |
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| Keywords: | Pregnane alkaloids Cytotoxic activity |
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