Two new 1,4-naphthoquinone derivatives from Impatiens balsamina L. flowers |
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| Institution: | 1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;2. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;1. Centre for Medical Parasitology, Department for Clinical Microbiology, Copenhagen University Hospital and Department of International Health, Immunology and Microbiology, University of Copenhagen, Denmark;2. Department for Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark;1. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan;2. Department of Geology, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan;3. Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan;4. Department of Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan;5. Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan;6. Department of Biotechnology, Sardar Bahadur Khan Women University, Quetta, Pakistan;1. Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100 ?zmir, Turkey;2. University of Salerno, Department of Pharmacy, 84084 Fisciano, Salerno, Italy;3. Ege University, Faculty of Science, Department of Botany, Bornova 35100, ?zmir, Turkey;1. Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;1. State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;2. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
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| Abstract: | Two new 1,4-naphthoquinone derivatives, balsaminone D (1), balsaminone E (2) along with two known compounds (3 and 4) were discovered from Impatiens balsamina L. flowers. Their structures were identified with spectroscopic methods including HR–EI–MS, 1D and 2D NMR, as well as the absolute configuration was determined by ECD calculation. In addition, new compounds 1 and 2 with IC50 value of 30.54 and 40.67 μg/mL exhibited better activities against activated t-HSC/Cl-6 cells than positive control Silymarin and Fufang Biejia Ruangan Pian, of which the IC50 value were 202.34 and 231.56 μg/mL, respectively. |
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| Keywords: | 1 4-Naphthoquinone Anti-hepatic fibrosis activity Electronic circular dichroism (ECD) |
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