New cis-ent-clerodanes from Linaria japonica |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China;4. Kunming Longjin Pharmaceutical Co., Ltd, Kunming 650503, PR China;1. Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China;2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;3. Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;4. Department of Pharmacy, Zhejiang University of Traditional Chinese Medicine, Zhejiang 310053, China |
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| Abstract: | Five new cis-ent-clerodanes, linarenones A–E (1–5) and two known compounds (6 and 7) were isolated from whole plant of Linaria japonica. The structures of these compounds were determined by various spectroscopic analyses (UV, IR, HR–ESI–MS, 1D and 2D NMR). The absolute configuration of five new diterpenoids was confirmed by circular dichroism (CD) analysis and chemical conversion. Cytotoxicity of the isolated compounds against A549 cell lines and Leishmania major were evaluated. The new cis-ent-clerodane 3 was found to be moderately active against A549 cell lines, and new cis-ent-clerodanes 1, 6 and desacetyl-linarienone (7) were active against L. major. |
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| Keywords: | Linarenone Cytotoxicity |
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