Two new spirostanol saponins from the the roots and rhizomes of Tupistra chinensis |
| |
| Affiliation: | 1. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;1. Graduate School, Department of Gynecology, Tianjin Medical University, Tianjin, China;2. Department of Biochemistry and Molecular Biology, Nankai University School of Medicine, Tianjin, China;3. Department of Gynecology, Tianjin Central Hospital for Obstetrics and Gynecology, Tianjin, China;1. Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan;2. Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal, Dir (U) 18000, Pakistan;3. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan;4. Department of Chemistry, University of Karachi, Karachi 75270, Pakistan;1. Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, ul. Czartoryskich 8, 24-100, Puławy, Poland;2. Medicinal and Aromatic Plants Research Department, National Research Centre, 12311, Dokki, Cairo, Egypt;3. Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland;1. Ovation Health Science and Technology Co., Ltd., ENN Group, Langfang 065001, PR China;2. Beijing Institute of Radiation Medicine, Beijing 100850, PR China;1. School of Pharmacy and Bioengineering, Chengdu University, Chengdu, 610106, China;2. Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, China;3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610013, China;4. Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing, 100026, China;5. Department of Chemistry, Women University of Azad Jammu and Kashmir, Bagh, 12500, Pakistan |
| |
| Abstract: | Two new spirostanol saponins (1) and (2), together with three known saponins (3–5), were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as (20S, 22R)-spirost-25(27)-en-1β, 3β, 4β, 5β-tetraol-5-O-β-d-glucopyranoside (1) and (20S, 22R)-spirost-25(27)-en-1β, 3β, 5β-triol-5-O-β-d-glucopyranoside (2), (20S, 22R)-spirost-25(27)-en-1β, 2β, 3β, 4β, 5β-pentaol-5-O-β-d-glucopyranoside (3), Δ25(27)-pentrogenin (4) and ranmogenin A (5) on the basis of physicochemical properties and spectral analysis. The isolated compounds were evaluated for their cytotoxic activities against A549 and H1299 tumor cell lines in vitro. Among them, compound 2 showed cytotoxicities against A549 cells (IC50 52.66 ± 3.12 μmol L−1) and H1299 cells (IC50 57.29 ± 2.51 μmol L−1), respectively. |
| |
| Keywords: | Liliaceae Spirostanol saponins Cytotoxicity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
