Xanthine oxidase inhibitors isolated from Piper nudibaccatum |
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| Affiliation: | 1. Key Laboratory of Economic Plants and Biotechnology, and Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People''s Republic of China;2. Key Laboratory Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People''s Republic of China;3. Graduate University of Chinese Academy of Sciences, Beijing 100049, People''s Republic of China;4. Biomedical Engineering Research Center, Kunming Medical University, Kunming 650500, People''s Republic of China;5. College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, People''s Republic of China;1. Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt;3. Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia;4. Suez Canal University Hospital, Suez Canal University, Ismailia 41522, Egypt;5. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;6. Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia;1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China;2. College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, PR China;1. Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand;2. Chulabhorn Graduate Institute and Center for Environmental Health and Toxicology (EHT), Kamphaeng Phet 6 Road, Bangkok 10210, Thailand;1. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I P.O. Box 812, Yaoundé, Cameroon;2. Higher Teachers’ Training College, University of Yaoundé I P.O. Box 47, Yaoundé, Cameroon;3. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA;4. Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, Nigeria;5. Institute für Pharmaceutische Biologie und Biotechnologie HEINRICH HEINE Universität Düsseldorf Universitat StraBe 1, Gebäude 26.23, 40225 Düsseldorf, Germany;1. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, Shandong, China;2. Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China |
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| Abstract: | Two new hydroxychavicol analogs nudibaccatumin A (1) and B (2), together with twenty known compounds were isolated from the methanol extract of Piper nudibaccatum. Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, UV, IR and polarimetry). Hydroxychavicol is a known inhibitor of xanthine oxidase (XO). In the present study, hydroxychavicol and 5 natural analogs (1–5) were evaluated for their XO inhibitory activity. Neotaiwanensol B (3) (IC50 = 0.28 μM) showed a greater inhibitory effect than hydroxychavicol and allopurinol (the positive control). Two new compounds 1 and 2 showed a moderate inhibition activity with an IC50 value of 62.94 μM and 70.67 μM, respectively. |
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| Keywords: | Hydroxychavicol Nudibaccatumin A Nudibaccatumin B Xanthine oxidase |
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