Dicorynamine and harmalan-N-oxide,two new β-carboline alkaloids from Dicorynia guianensis Amsh heartwood |
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| Institution: | 1. Laboratoire de Nutrition et Pharmacologie, UFR Biosciences, Université Felix Houphouët Boigny de Cocody-Abidjan, 22, BP 582 Abidjan 22, Cote d’Ivoire;2. LAPISEN, Groupe de recherche en Chimie des Eaux et des Substances Naturelles, Institut National Polytechnique Houphouët Boigny, BP 1313 Yamoussoukro, Cote d’Ivoire;3. CNRS, UPMC, LBBM, Observatoire Océanologique, 66650 Banyuls-sur-Mer, France;4. Laboratoire de Chimie Organique, UFR Sciences des Structures de la Matière et de Technologie, Université Felix Houphouet Boigny, 22, BP 582 Abidjan 22, Cote d’Ivoire;5. L3MA, UMR Ecologie des Forêts de Guyane, Université des Antilles et de Guyane, Campus de Troubiran, 97300 Cayenne, France;6. AM2N, Institut Charles Gerhardt, UMR 5253, ENSCM, 8 rue de l’Ecole Normale, 34296 Montpelier, France;7. CIRAD, Département Environnements et Sociétés, UMR Ecologie des Forêts de Guyane, BP 732, 97310 Kourou cedex, France;1. Department of Health Law and Economics, School of Pharmacy, University Paris Descartes, 4, avenue de l’Observatoire, 75006 Paris, France;2. Berkeley Center for Health Technology, University of California, Berkeley, CA, United States;3. Department of Health Policy, Milken Institute School of Public Health, George Washington University, Washington DC, 950 New Hampshire Avenue, NW 7th Floor, Washington, DC 20052 United States;4. LWC Health Pty Ltd, Canberra, Australia;5. Department of Microbiology, School of Pharmacy, University of Paris Sud, 92296 Châtenay-Malabry cedex, France;6. GRADES University of Paris Sud, 5, rue Jean-Baptiste-Clément, 92296 Châtenay-Malabry cedex, France;7. Académie nationale de pharmacie, 4, avenue de l’Observatoire, 75006 Paris, France;1. Institute of Theoretical Chemistry, Jilin University, Changchun 130023, China;2. School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China;1. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, PR China;2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming Medical University, Kunming 650500, PR China;1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;2. Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia;3. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt;4. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;5. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt;6. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt;1. College of Chemistry and Chemical Engineering, Key Laboratory of Clean Energy Materials Chemistry of Guangdong Higher Education Institute, Lingnan Normal University, Zhanjiang, 524048, PR China;2. Yosemade Medicine Research Institution RM 4-202, NO 291 Fucheng Heda Pharmaceutical Valley Center Xiasha, Jianggan, Hangzhou, Zhejiang, 310018, PR China |
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| Abstract: | The chemical investigations of Dicorynia guianensis heartwood led to the isolation of four new indole alkaloids for the first time in this plant. Compound (1) identified as spiroindolone 2′,3′,4′,9′-tetrahydrospiro indoline-3,1′pyrido3,4-b]-indol]-2-one, and compound (3) described as nitrone 1-methyl-4,9-dihydro-3H-pyrido 3,4-b] indole 2-oxide and were isolated for the first time as natural products. ABTS antioxidant activity guided their isolation. |
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| Keywords: | Spiroindolone Nitrone ABTS antioxidant Biogenesis |
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