Three new flavones from the roots and stems of Tiandeng tobacco and their anti-TMV activities |
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| Affiliation: | 1. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, PR China;2. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products, Kunming Medical University, Kunming 650500, PR China;1. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;1. Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand;2. Chulabhorn Research Institute, Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand;3. Center of Excellence on Environmental Health and Toxicology, CHE, Ministry of Education, Thailand;1. Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, Yunnan, PR China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, University of Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China;1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China;2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China;1. School of Pharmaceutical Science, Hainan Medical University, Haikou 571101, China;2. Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China;3. Hainan Provincial Institute for Drug and Food Control, Haikou 570216, China;1. Key Laboratory of Tobacco Diseases and Insect Pests Monitoring Controlling and Integrated Management, Institute of Tobacco Research, Chinese Academy of Agricultural Sciences, Qingdao 266101, China;2. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China |
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| Abstract: | Three new flavone derivatives, paranicflavones A–C (1–3), together with three known similar compounds (4–6), were isolated from their roots and stems of Tiandeng tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1H and 13C NMR techniques. Additionally, compounds 1–6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities, and compound 2 exhibited anti-TMV activity with inhibition rate of 35.8%, which is higher than that of positive control, ningnanmycin. |
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| Keywords: | Tiandeng tobacco Flavone derivatives Anti-tobacco mosaic virus activity |
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